No surprise. Most smart/intellectual characters seem to show negligence to someone, if not everyone. Not because they're jerks right from the start, by mainly it's kind of a construct for character development.
Oh man poor Spike, now that is some dedication, He definitely lives up to his title as number one assistant. I hope his friends help take care of him as well as they would Twilight (I know Fluttershy would).
Twilight was being obsessive, stalking her friend, and putting herself in the line of fire based on the plot of the episode. This was the perfect fuel for appropriate slapstick. She is the show's protagonist to boot.
Spike has bad things happening much, MUCH more frequently to him, and mostly because of negligience on Twilight's part.